Cellular Repair/Misrepair Track Model
نویسندگان
چکیده
Public reporting burden for this collection of information is estimated to average 1 hour per response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed, and completing and reviewing the collection of information. Send comments regarding this burden estimate or any other aspect of this collection of information, including suggestions for reducing this burden,
منابع مشابه
The link between low-LET dose-response relations and the underlying kinetics of damage production/repair/misrepair.
PURPOSE To review current opinion on the production and temporal evolution of low-LET radiobiological damage. METHODS Standard cell survival models which model repair/misrepair kinetics in order to quantify dose-response relations and dose-protraction effects are reviewed and interrelated. Extensions of the models to endpoints other than cell survival, to multiple or compound damage processin...
متن کاملA Markov Model of the Repair-misrepair Process of Cell Survival
The repair-misrepair model of cell survival is formulated mathematically as a Markov process. The nucleus of a cell is described by the status of the lesions that resulted from exposure to radiation. At any time each of these lesions is either unrepaired, misrepaired, or eurepaired. A system of coupled differential equations for the probabilities of zero, one, two, ... unrepaired lesions is der...
متن کاملAging as a process of accumulation of Misrepairs
We recently introduced Misrepair-accumulation theory as an interpretation on aging mechanism. For better understanding this theory, we discuss here in more details the new concept of Misrepair and the concept of accumulation of Misrepairs. I. Aging takes place uniquely on the systems that have a well-defined structure: an organization of its substructures. Aging of a non-living system is a resu...
متن کاملCombined use of Monte Carlo DNA damage simulations and deterministic repair models to examine putative mechanisms of cell killing.
A kinetic repair-misrepair-fixation (RMF) model is developed to better link double-strand break (DSB) induction to reproductive cell death. Formulas linking linear-quadratic (LQ) model radiosensitivity parameters to DSB induction and repair explicitly account for the contribution to cell killing of unrejoinable DSBs, misrepaired and fixed DSBs, and exchanges formed through intra- and intertrack...
متن کاملGeneralized time-dependent model of radiation-induced chromosomal aberrations in normal and repair-deficient human cells.
We have developed a model that can simulate the yield of radiation-induced chromosomal aberrations (CAs) and unrejoined chromosome breaks in normal and repair-deficient cells. The model predicts the kinetics of chromosomal aberration formation after exposure in the G₀/G₁ phase of the cell cycle to either low- or high-LET radiation. A previously formulated model based on a stochastic Monte Carlo...
متن کامل